Representative picture

Washington [US]June 29 (ANI): According to a new study, a maternal diet high in omega-3 fatty acids may protect against developing breast cancer in the offspring.

The results of the study were published in the journal “Frontiers in Cell and Developmental Biology”.

The researchers found a significant difference in mice from mothers who were fed a diet high in canola oil compared to mothers who were fed a diet high in corn oil. A maternal omega-3-rich diet influenced genome-wide changes in the epigenetic landscape of the offspring and possibly modulated gene expression patterns.

Dr. Ata Abbas, a former postdoctoral fellow at the Marshall Department of Biological Sciences, led a research team led by Dr. Philippe Georgel at the College of Science. The research was conducted at the Cell Differentiation and Development Center in Marshall as part of a collaboration with the Department of Biochemistry and Microbiology at the Joan C. Edwards School of Medicine under the direction of Dr. W. Elaine Hardman performed.

Researchers found a three-week delay in mortality in mice fed mothers canola oil versus corn oil. The early delay in mortality was significantly different, but the final overall survival rate was not.

Eventually, all of the mice developed tumors, but those fed the canola oil had tumors that grew slower and were smaller than the mice fed the corn oil. Applied to the human time scale, the duration of the protective effect in connection with maternal nutrition would correspond to several months.

This study is part of the work of researchers at Marshall University and others investigating the link between omega-3 fatty acids and a reduced incidence of various cancers, including, but not limited to, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.

“Parental nutrition and intergenerational transmission has become an important area of ​​research, but how it works often remains elusive,” said Georgel, professor in Marshall’s Department of Biological Sciences.

“The MU research group focused on ‘epigenetic’ aspects of transgenerational transmission to explain the reported role of omega-3 fatty acids. Epigenetics involves changes in gene expression that are not related to changes in genetic sequences, ”added Georgel.

“These results have the potential to encourage simple dietary changes that will reduce the incidence of various types of cancer, not just in those who follow this diet but also in their offspring,” concluded Georgel. (ANI)


Please enter your comment!
Please enter your name here