“There was a statistically significant relative risk reduction of 18% in vascular death, defined as death from CAD, stroke, or other vascular causes …”

NEW ORLEANS – Research from 1944 found that Greenland Inuit, who, despite a high-fat diet, had a lower incidence of coronary artery disease (CHD) – particularly due to the type of fat in their diet that was rich in fish (Seal & Whale), despite a low consumption of fruits and vegetables.

It was found that the reduction in risk of coronary artery disease in the Inuits was partly due to a high intake of omega-3 polyunsaturated fatty acids in their fish selections, which provide high-risk (TG) triglyceride (TG) reduction benefits. anti-inflammatory and antiarrhythmic effects, vasodilation, decreased blood pressure, improved arterial and endothelial function, favorable autonomic tone and decreased platelet aggregation.

According to “An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health” published in the online journal Nutrients in January 2021, “TG levels are a historically well-studied, independent risk factor for CHD. It has been shown that dietary supplementation with Ω-3 (omega-3) or a dose of fish oil reduces TG levels in a dose-dependent manner, with 3–4 g / day of eicosapentaenoic acid (EPA) or a combined EPA and docosahexaenoic acid (DHA) lowering blood levels in patients with high TGs by 20–50%. “

I had the special pleasure of working with one of the study authors, Dr. Carl J. Lavie, Department of Cardiovascular Disease, John Ochsner Cardiovascular Institute, Ochsner Clinic School, University of Queensland Medical School, New Orleans, to collaborate and learn from them during my previous tenure as Director of Health and Fitness for Lavie’s Institute.

To this day, Lavie provides cardiovascular testing interpretation for my diverse customer population.

In their review of omega-3 history and research, Lavie and his fellow students note previous controversies over the supposed omega-3 benefits of the popular media, “which falsely indicated that Ω-3 intake, including that of fish , Prostate cancer increases risk, with many comments advising against the use of additional fish oil afterwards. “

On the contrary, the study’s researchers comment, “However, the habitually high intake of seafood in men with prostate cancer has been linked to a significant improvement in survival. Accordingly, Japanese men who consume roughly eight times more fish than their American counterparts have a multiple lower prostate cancer mortality rate. “

Investigators also found that three major studies contributed to the omega-3 controversy in 2018.

The ASCEND study found that the risk of cardiovascular disease (CVD) was not reduced when using 1 gram of EPA plus DHA per day for primary prevention in patients with diabetes. “There was no significantly reduced incidence of major vascular events in 15,480 patients after an average of 7.4 years of follow-up.”

However, the study’s authors comment, “There was a statistically significant relative risk reduction of 18% in vascular death, defined as death from CAD, stroke, or other vascular causes, which appears to be a meaningful endpoint that was not highlighted in this article. “

In the VITAL study, in which 2000 IU / day vitamin D3 and 1 gram / day Ω-3 (EPA + DHA) were administered for the primary prevention of CVD and cancer in 25,871 patients, there was no median difference between the intervention and the placebo group of 5.3 years.

“However, this study, similar to ASCEND, also found a statistically significant reduction in overall MI (myocardial infarction),” according to the Omega-3 Research Report.

The REDUCE-IT study enrolled 8,179 patients with established CVD or diabetes who received statin therapy with TG levels of 135-499 milligrams per deciliter (mg / dL) and low-density lipoprotein levels of four grams per day of a highly purified form of EPA , administered per day 41-100 mg / dl.

It was found that “the primary endpoint (composed of CVD death, non-fatal MI, non-fatal stroke, CV revascularization, or unstable angina pectoris) was reduced by 25% in the treatment group.”

The researchers suggest that the omega-3 index, a blood test, is an objective measurement of endogenous (internal) omega-3 levels – specifically for EPA and DHA status. It can be used to assess baseline omega-3 status and response to omega-3 therapy as a clinical life course health goal.

The research team concluded that “decades and countless dollars have been spent studying the relationship between Ω-3 and CVD without reaching consensus among clinicians. However, there is strong evidence from multiple studies that higher doses of Ω-3 (2-4 g / day EPA + DHA) appear to be safe and appear to reduce CVD events in multiple CVD populations, suggesting further investigation for definitive Determination justifies the potential benefits of this safe, inexpensive, and well-tolerated therapy. ”

If you’d like to read this open access research and much more, please visit maxwellnutriton.com under “Open Access Research” at the bottom of the home page.

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